This website uses cookies. By continuing you are agreeing to our privacy policy.

Dmitri Petrov, Ph.D.

Dmitri Petrov
The Board of Trustees of the Leland Stanford Junior University (Stanford)
Barcoding Genetic Changes May Give Insight Into Lung Cancer
Lung Cancer Discovery Award

Lung cancer is an extremely complex disease because it is driven by a constellation of distinct genetic changes. Cancer sequencing efforts have defined prevalent genetic changes common in tumors. But how these genetic changes work together to drive tumor growth remains to be determined. We plan to dramatically improve a very powerful preclinical model of cancer that we developed previously. Our approach, called Tuba-seq, allows us to grow and follow individually tens of thousands of individual tumors in the mouse lung. Tuba-seq barcodes each tumor to uniquely identify the genetic changes and quantify tumor size. These tumors have predefined genetic changes generated using CRISPR and other techniques. CRISPR is a new kind of genetic engineering that allows scientists to edit DNA much more easily than before. We will extend Tuba-seq to allow creation of more complex and more realistic tumor genotypes (the set of genes in DNA responsible for a particular trait) necessary for modeling of human tumors.

Red button with telephone
Ask An Expert

Questions about your lung health? Need help finding healthcare? Call 1-800-LUNGUSA.

Get help
Red button of two hand prints
We need your generous support

Make a difference by delivering research, education and advocacy to those impacted by lung disease.

Button of turquoise LUNG FORCE swirl

LUNG FORCE unites women and their loved ones across the country to stand together in the fight against lung cancer.

Get involved
Join the fight for healthy lungs and healthy air.
Donate Now.


Breathe Easy

Give today and your tax-deductible gift will go TWICE as far for everyone who struggles to breathe.