This website uses cookies. By continuing you are agreeing to our privacy policy.

Limo Chen, Ph.D.

Limo Chen
University of Texas M.D. Anderson Cancer Center
Targeting Protein to Improve Immunotherapy for Lung Cancer
Lung Cancer Discovery Award

Although immunotherapy shows great promise in improving survival for lung cancer patients, resistance to therapy is a barrier in reducing patient deaths. Immunotherapy is the use of medicines to stimulate a person's own immune system to recognize and destroy cancer cells more effectively. Some lung cancer immunotherapy targets PD-1 and PD-L1, proteins that are found on some tumor cells and immune cells. Blocking these proteins can help boost the immune response against cancer cells. In mouse lung cancer models, we have seen that the failure of anti-PD-1/PD-L1 treatment is associated with an increase in activity of a protein on the surface of immune cells called CD38. We will study the role of CD38 in resistance to PD-1/PD-L1 treatment. The findings can lead to the development of new lung cancer treatment strategies.

Red button with telephone
Ask An Expert

Questions about your lung health? Need help finding healthcare? Call 1-800-LUNGUSA.

Get help
Red button of two hand prints
We need your generous support

Make a difference by delivering research, education and advocacy to those impacted by lung disease.

Button of turquoise LUNG FORCE swirl

LUNG FORCE unites women and their loved ones across the country to stand together in the fight against lung cancer.

Get involved
Join the fight for healthy lungs and healthy air.
Donate Now.


Breathe Easy

Give today and your tax-deductible gift will go TWICE as far for everyone who struggles to breathe.